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1029919 2010 年 09 月 27 日 09:13 Reading (loading. ..) Comments (0) Category: Science
Berger SI, Ma'ayan A, Iyengar R. Systems pharmacology of arrhythmias. Sci Signal. 2010 Apr 20; 3 (118): ra30.
Abstract | Full Text (PDF) | Full Text (HTML)
Led by biochemist Ravi Iyengar, the researchers specifically wanted to understand how drugs can produce a side effect similar to the heart arrhythmias seen in people with a congenital condition called long QT syndrome, which causes a prolonged \electrical cycle.
Scientists have identified 13 genes associated with long QT,
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To prove this, the researchers started with the currently known human interactome-a map of some 11,000 human proteins and their interactions. Using computation, they narrowed it down to the proteins associated with the long QT genes.
They found that these 1,
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Iyengar says these results show that complex diseases can have identifiable boundaries yet may share common molecular features. The overlap, he adds, also indicates that people who have one disease may have the propensity to develop the others.
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